IMMUNOLOGIA (IGG)

Investigador Principal: Jorge Carrillo

Presentació

El Grup d'Immunologia (IgG) és un grup de recerca d'IrsiCaixa creat l’any 2020, dirigit per Jorge Carrillo i format per investigadors post-doctorals i pre-doctorals apassionats per la seva feina. La principal línia d'investigació del grup és la caracterització de la resposta immunitària a les malalties infeccioses (principalment, però no exclusivament, el VIH), el càncer i l'autoimmunitat. Actualment està duent a terme la caracterització de la resposta humoral contra el VIH i el SARS-CoV-2, especialment la identificació d'anticossos neutralitzants, anticossos que interfereixen en la neutralització i anticossos patogènics. A més a més, l’equip del Dr Carrillo treballa en el desenvolupament de vacunes contra patògens complexos (com el VIH, el Treponema i el SARS-CoV-2), anticossos terapèutics i noves eines de diagnòstic.

Paraules clau: Anticossos neutralitzants, proteïnes recombinants, resposta humoral, vacunes centrades en cèl·lules B, immunogenicitat, SARS-CoV-2

Investigador Principal

Jorge Carrillo

...

Currículum

Línies estratègiques

Línies de recerca

Generació i aïllament d'anticossos monoclonals
Caracterització de la resposta immunològica contra el VIH i altres malalties
Desenvolupament de vacune

Projectes

RBD Dimer recombinant protein vaccine against SARS-CoV-2

Data: 12/2021 - 05/2024 Investigadors/es principals: Ester Ballana Guix, Julià Blanco, Christian Brander, Cecilia Cabrera, Jorge Carrillo, Núria de la Iglesia, Julia García Prado, Nuria Izquierdo-Useros, Miguel Ángel Martínez, Javier Martínez-Picado, Marta Massanella, Roger Paredes

Desenvolupament d’una nova vacuna contra SARS-CoV-2 (SLD0015)

Data: 01/01/2020 - 31/12/2020 Investigadors/es principals: Jorge Carrillo, Joaquim Segalés (IRTA-CReSA), Alfonso Valencia (BSC)

Descriure el paper de la resposta humoral en el desenvolupament de la infecció greu pel SARS-CoV-2 durant la infecció natural i després de la immunització

Data: 09/2021 - 09/2023 Investigadors/es principals: Jorge Carrillo, Júlia Vergara-Alert

Macrophages autophagy as a MoA of IVIG

Data: 10/09/2020 - 31/07/2021 Investigadors/es principals: Cecilia Cabrera, Jordi Senserrich, Bonaventura Clotet

Fostering prophylactic and therapeutic strategies to fight the SARS-CoV-2 pandemic

Data: 03/20 - 03/22 Investigadors/es principals: Bonaventura Clotet, Julià Blanco, Jorge Carrillo, Nuria Izquierdo-Useros, Joquim Segalés, Julia Vergara-Alert, Alfonso Valencia, Victor Guallard

Antiviral activity of Aplidin

Data: 2020 - 2021 Investigadors/es principals: Nuria Izquierdo-Useros

Identificación, aislamiento y caracterización de anticuerpos que interfieren con la acción de los anticuerpos neutralizantes en personas infectadas por el virus de la inmunodeficiencia humana

Data: 01/01/2019 - 31/12/2021 Investigadors/es principals: Jorge Carrillo

Characterization of the humoral response to SARS-CoV-2. Implication for vaccine development

Data: 05/2020 - 12/2021 Investigadors/es principals: Jorge Carrillo

Publicacions

Stable neutralizing antibody levels 6 months after mild and severe COVID-19 episodes

Revista: Med Any: 2021

Humoral immune responses and neutralizing antibodies against SARS-CoV-2; implications in pathogenesis and protective immunity

Revista: Biochemical and Biophysical Research Communications Any: 2021

SARS-CoV-2 infection elicits a rapid neutralizing antibody response that correlates with disease severity

Revista: Scientific Reports Any: 2021

SARS-CoV-2 Cellular Infection and Therapeutic Opportunities: Lessons Learned from Ebola Virus

Revista: Membranes Any: 2021

A Longitudinal Analysis Reveals Early Activation and Late Alterations in B Cells During Primary HIV Infection in Mozambican Adults

Revista: Frontiers in Immunology Any: 2021

Impact of Long-Term Cryopreservation on Blood Immune Cell Markers in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Implications for Biomarker Discovery

Revista: Frontiers in Immunology Any: 2020

Predicting Antibody Neutralization Efficacy in Hypermutated Epitopes Using Monte Carlo Simulations

Revista: Polymers Any: 2020

Outcome of hospitalized patients with COVID-19 pneumonia treated with high-dose immunoglobulin therapy in a prospective case series

Revista: Clinical Microbiology and Infection Any: 2020

Detection of SARS-CoV-2 in a cat owned by a COVID-19−affected patient in Spain

Revista: PNAS Any: 2020

Pigs are not susceptible to SARS‐CoV‐2 infection but are a model for viral immunogenicity studies

Revista: Transboundary and Emerging Diseases Any: 2020

Neoantigen prediction and computational perspectives towards clinical benefit: recommendations from the ESMO Precision Medicine Working Group

Revista: Annals of Oncology Any: 2020

Gut T cell-independent IgA responses to commensal bacteria require engagement of the TACI receptor on B cells

Revista: Science Immunology Any: 2020

Assessment of the Feasibility and Safety of Durvalumab for Treatment of Solid Tumors in Patients With HIV-1 Infection: The Phase 2 DURVAST Study

Revista: JAMA Oncology Any: 2020

Methylation regulation of antiviral host factors, Interferon Stimulated Genes (ISGs) and T-cell responses associated with natural HIV control

Revista: PLOS Pathogens Any: 2020

New emerging targets in cancer immunotherapy: the role of neoantigens

Revista: ESMO Open Any: 2020

Production of HIV-1-based virus-like particles for vaccination: achievements and limits

Revista: Applied Microbiology and Biotechnology Any: 2019

Different pattern of stool and plasma gastrointestinal damage biomarkers during primary and chronic HIV infection

Revista: PLoS One Any: 2019

Evolution of the gut microbiome following acute HIV-1 infection

Revista: Microbiome Any: 2019

Antibodies and Antibody Derivatives: New Partners in HIV Eradication Strategies

Revista: Frontiers in Immunology Any: 2018

Secreted IgD Amplifies Humoral T Helper 2 Cell Responses by Binding Basophils via Galectin-9 and CD44

Revista: Immunity Any: 2018

Low nadir CD4+ T-cell counts predict gut dysbiosis in HIV-1 infection

Revista: Mucosal Immunology Any: 2018

Unexpected synergistic HIV neutralization by a triple microbicide produced in rice endosperm

Revista: PNAS Any: 2018

Dynamics of CD4 and CD8 T-Cell Subsets and Inflammatory Biomarkers during Early and Chronic HIV Infection in Mozambican Adults

Revista: Frontiers in Immunology Any: 2018

Memory B cell dysregulation in HIV-1-infected individuals

Revista: AIDS Any: 2017

Virological and immunological outcome of treatment interruption in HIV-1-infected subjects vaccinated with MVA-B

Revista: PLOS ONE Any: 2017

Elevated humoral response to cytomegalovirus in HIV-infected individuals with poor CD4+ T-cell immune recovery

Revista: PLoS One Any: 2017

Immunologic Insights on the Membrane Proximal External Region: A Major Human Immunodeficiency Virus Type-1 Vaccine Target

Revista: Frontiers in Immunology Any: 2017

IP-10 Levels as an Accurate Screening Tool to Detect Acute HIV Infection in Resource-Limited Settings

Revista: Scientific Reports Any: 2017

Interferon-γ-Inducible Protein 10 (IP-10) as a Screening Tool to Optimize Human Immunodeficiency Virus RNA Monitoring in Resource-Limited Settings

Revista: Clinical Infectious Diseases Any: 2017

Proteoliposomal formulations of an HIV-1 gp41-based miniprotein elicit a lipid-dependent immunodominant response overlapping the 2F5 binding motif

Revista: Scientific Reports Any: 2017

A cytokine pattern that differentiates pre- from post- seroconversion phases of primary HIV infection

Revista: JAIDS - Journal of Acquired Immune Deficiency Syndromes Any: 2016

Antiretroviral therapy suppressed participants with low CD4+ T-cell counts segregate according to opposite immunological phenotypes

Revista: AIDS Any: 2016

Gut Microbiota Linked to Sexual Preference and HIV Infection

Revista: EBioMedicine Any: 2016

Gp120/CD4 Blocking Antibodies Are Frequently Elicited in ART-Naïve Chronically HIV-1 Infected Individuals

Revista: PLOS One Any: 2015

Increased ex vivo cell death of central memory CD4 T cells in treated HIV infected individuals with unsatisfactory immune recovery

Revista: Journal of Translational Medicine Any: 2015

Equip

Investigador/a post-doctoral

Mª Luisa Rodríguez de la Concepción

mlrodriguez@irsicaixa.es

Investigador/a pre-doctoral

Carlos Ávila Nieto

cavila@irsicaixa.es

Investigador/a principal

Jorge Carrillo

jcarrillo@irsicaixa.es

Investigador/a post-doctoral

Erola Ainsua Enrich

eainsua@irsicaixa.es

Investigador/a post-doctoral

Núria Pedreño López

npedreno@irsicaixa.es

Notícies del grup

Un nou dispositiu utilitza llum per detectar de forma eficient la COVID-19 en mostres de saliva

Administrar immunoglobulines pot millorar l’evolució de les persones amb una COVID-19 greu

Impulsat per:

Fundació 'La Caixa'

Membre de:

Amb la col·laboració de: