Publicacions
El coneixement generat a IrsiCaixa es comparteix amb la comunitat científica a través de la publicació d’articles a revistes científiques d’alt impacte.
Palbociclib, a selective inhibitor of cyclin-dependent kinase4/6, blocks HIV-1 reverse transcription through the control of sterile α motif and HD domain-containing protein-1 (SAMHD1) activity.
Gene editing using a zinc-finger nuclease mimicking the CCR5Δ32 mutation induces resistance to CCR5-using HIV-1.
HLA class I protective alleles in an HIV-1-infected subject homozygous for CCR5-Δ32/Δ32.
Nucleotide embargo by SAMHD1: a strategy to block retroviral infection.
The cortical actin determines different susceptibility of naïve and memory CD4+ T cells to HIV-1 cell-to-cell transmission and infection.
Restriction of HIV-1 replication in primary macrophages by IL-12 and IL-18 through the upregulation of SAMHD1.
Polymorphic LEDGF/p75 variants support efficient HIV-1 infection ex vivo.
Insights from host genomics into HIV infection and disease: Identification of host targets for drug development.
Antiretroviral agents effectively block HIV replication after cell-to-cell transfer.
Differential prevalence of the HLA-C -- 35 CC genotype among viremic long term non-progressor and elite controller HIV+ individuals.