Benjamin Trinité
Benjamin Trinité obtained a degree in Physiology and Immunology from the University of Rouen in 1999. During his master’s studies he joined the group of Dr Regis Josien at the Institute of Transplantation and Research in Transplantation (ITERT), INSERM U643 (now Centre de Recherche en Transplantation et Immunologie CRTI UMR 1064) in Nantes, where he later undertook his doctoral training and studied dendritic cell biology.
In 2004 he started postdoctoral training at UPenn (Philadelphia, USA) in the group of Dr Yongwon Choi, studying the role of TRAF6 signalling in dendritic cell development and function. Next he joined the group of Dr Julie Blander at Mount Sinai School of Medicine in New York, where he studied regulation of cross-presentation by TLR signalling. In 2010 he joined the group of Dr David N. Levy at New York University as Associate Research Scientist, focusing his research on the interplay between HIV-1 and resting CD4 T-cells. His work contributed to the notion that HIV-1 is well adapted to replicating within resting CD4 T-cells. He also showed that FoxO1 signalling and HIV-1 expression are mutually antagonistic and demonstrated that, in certain conditions, unintegrated HIV-1 DNA genomes can support viral replication.
In 2018, Benjamin joined IrsiCaixa’s Cell Virology and Immunology (VIC) group headed by Dr Julià Blanco.
Immunization with V987H-stabilized Spike glycoprotein protects K18-hACE2 mice and golden Syrian hamsters upon SARS-CoV-2 infection.
Immunisation efficacy of a stabilised SARS-CoV-2 spike glycoprotein in two geriatric animal models.
A monoclonal antibody targeting a large surface of the receptor binding motif shows pan-neutralizing SARS-CoV-2 activity.
Virus-like particle-mediated delivery of structure-selected neoantigens demonstrates immunogenicity and antitumoral activity in mice.
Safety and immunogenicity of a recombinant protein RBD fusion heterodimer vaccine against SARS-CoV-2.