Treatment options after virological failure of first-line tenofovir-based regimens in South Africa: an analysis by deep sequencing

Treatment options after virological failure of first-line tenofovir-based regimens in South Africa: an analysis by deep sequencing

Online publication: 24/04/2016 Journal: AIDS

Abstract:

In a South African cohort of participants living with HIV developing virological failure on first-line tenofovir disoproxyl fumarate (TDF)-basedregimens, at least 70% of participants demonstrated TDF resistance according to combined Sanger and MiSeq genotyping. Sanger sequencingmissed the K65R mutation in 30% of samples. Unless HIV genotyping is available to closely monitor epidemiological HIV resistance to TDF, its efficacy as second-line therapy will be greatly compromised.

Authors: Casadellà, M., Noguera-Julian, M., Sunpath, H., Gordon, M., Rodriguez, C., Parera, M., Kuritzkes, D.R., Marconi, V.C., Paredes, R.

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