Cyclin-dependent Kinases as Emerging Targets for Developing Novel Antiviral Therapeutics

Cyclin-dependent Kinases as Emerging Targets for Developing Novel Antiviral Therapeutics

Fecha de publicación online: 01/02/2021 Fecha de publicación en papel: 1 Febrero 2021 Revista: Trends in Microbiology

Abstract:

Besides its prominent role in cell proliferation, cyclin-dependent kinases (CDKs) are key players in viral infections as both DNA and RNA viruses modify CDK function to favor viral replication. Recently, a number of specific pharmacological CDK inhibitors have been developed and approved for cancer treatment. The repurposing of these specific CDK inhibitors for the treatment of viral infections may represent a novel effective therapeutic strategy to combat old and emergent viruses. In this review, we describe the role, mechanisms of action, and potential of CDKs as antiviral drug targets. We also discuss the current clinical state of novel specific CDK inhibitors, focusing on their putative use as antivirals, especially against new emerging viruses.

Autores: Gutierrez-Chamorro L, Felip E, Ezeonwumelu IJ, Margelí M, Ballana E

Suscríbete a la newsletter

Back to Top
Irsi Caixa

Impulsado por:

Fundación 'La Caixa' Generalitat de Catalunya - Departament de Salut

 

HR Excellence in Research

Miembro de:

Cerca

Con la colaboración de: