HIV-infection, immunosenescence and genomic instability: Identification of biomarkers in chronic HIV infected patients and its relationship with premature aging (PI19/00947)

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HIV-infection, immunosenescence and genomic instability: Identification of biomarkers in chronic HIV infected patients and its relationship with premature aging (PI19/00947)

2020-2022

Principal Investigators: Marta Massanella, Eugenia Negredo (Fundació Lluita contra la Sida) , Marta Martin (UAB)

HIV-infected patients present a higher prevalence of morbidities and immunosenescence (aging of the immune system). In aged organisms, the accumulation of cells with unrepaired DNA lesions contributes to genome instability, rendering them more susceptible to enter senescence. Although genomic instability is one of the hallmarks of aging and senescence, the relationship between immunosenescence and genomic instability remains to be described/has not been assessed. The overall objective of the project is to determine the prevalence of immunosenescence, cellular aging and senescence markers (shortening of telomeres, DNA damage, 53BP1 recruitment, cell proliferation capacity and expression of senescence markers) in HIV-infected and uninfected adults (40-45 years) and elderly (60-70 years).

We aim to:

  1. Establish the relation between these two mechanisms (immunosenescence and cellular aging/senescence 
  2. Determine if HIV induces them earlier and in a more accelerated way 
  3. Characterize target biomarkers that would allow their surveillance in these patients.

 

  • Funding entity: Ministry of Science, Innovation and Universitites - Carlos III Health Institute (ISCIII)

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  • Participant entities: IrsiCaixa AIDS Research Institute, Fight AIDS and Infectious Diseases Foundation, Universitat Autònoma de Barcelona (UAB)

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Irsi Caixa

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'La Caixa' Foundation Generalitat de Catalunya - Departament de Salut

 

HR Excellence in Research

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