Viral evolution during structured treatment interruptions in chronically human immunodeficiency virus-infected individuals

Viral evolution during structured treatment interruptions in chronically human immunodeficiency virus-infected individuals

Online publication: 01/12/2002 Printed publication: 1 December 2002 Journal: Journal of Virology

Abstract:

We analyzed the evolution of the human immunodeficiency virus type 1 (HIV-1) env gene in 12 chronically infected individuals who underwent structured treatment interruptions (STIs). Analyses of length variation and of clonal sequences demonstrated highly unpredictable evolution, which may limit the strengthening of HIV-specific immune responses by STIs because of the variability in exposure to viral antigens.

Authors: Martinez-Picado J, Frost SD, Izquierdo N, Morales-Lopetegi K, Marfil S, Puig T, Cabrera C, Clotet B, Ruiz L.

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