HIV and HCV Genetic and Phenotypic Variability

HIV AND HCV GENETIC AND PHENOTYPIC VARIABILITY

Principal Investigator: Miguel Ángel Martínez

Presentation

The research interests of our group are focused in understand the molecular mechanisms implicated in human viruses' pathogenesis. In the last two decades, we have been studying how the genetic variability of HIV-1 and HCV has influenced virus pathogenesis, immunogenicity and response to antiviral therapy. Recently, we have explored how synonymous codon mutations impact HIV-1 protein expression and virus replication capacity. Codon or codon pair biases and HIV-1 RNA dinucleotide frequencies (e.g., CpG/UpA) affect host innate response, virus latency and pathogenesis. In relation to our work with HCV, we are quantifying the levels of plasma circulating microRNAs (miRNAs) as biomarkers of liver disease progression in HIV-1 and/or HCV infected patients. miRNAs are predicted to regulate over half of the human transcriptome. The lack of available biomarkers for diagnosing and predicting different stages of liver disease (e.g., NAFLD and NASH) is currently one of the main challenges that clinicians are facing. Lastly, we have hypothesized that circulating miRNAs may be biomarkers of SARS-CoV-2 infection and subsequent manifestation and progression of COVID-19.

Keywords: Virus, HIV, HCV, evolution
Principal Investigator

Miguel Ángel Martínez

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Curriculum

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Irsi Caixa

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'La Caixa' Foundation Generalitat de Catalunya - Departament de Salut

 

HR Excellence in Research

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