Highly immunogenic HIV p24 sequences

Highly immunogenic HIV p24 sequences

Presentation date: 10/11/2011 Inventors: Beatriz Mothe, Christian Brander, James I. Mullins

The invention relates to peptides comprising part or all of a conserved element within a Center-of-Tree (COT) sequence derived from a family of polypeptides encoded by naturally occurring variants of HIV. The invention also relates to immunogenic compositions and vaccines comprising said peptides. The invention also relates to methods for the identification of HIV controller patients based on the detection of the T cells of the patient to mount a cytotoxic T cell response against said peptides and to methods for the identification of immunogenic peptides within a family of variant polypeptides.



Publication number: 1040
Application number: PCT/EP2011/069870
Institution: Laboratorios del Dr. Esteve, SA, University of Washington, Institució Catalana de Recerca i Estudis Avançats (ICREA), Institut de Recerca de la Sida IrsiCaixa
IrsiCaixa inventors: Beatriz Mothe, Christian Brander

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