Viral evolution during structured treatment interruptions in chronically human immunodeficiency virus-infected individuals

Viral evolution during structured treatment interruptions in chronically human immunodeficiency virus-infected individuals

Fecha de publicación online: 01/12/2002 Fecha de publicación en papel: 1 Diciembre 2002 Revista: Journal of Virology

Abstract:

We analyzed the evolution of the human immunodeficiency virus type 1 (HIV-1) env gene in 12 chronically infected individuals who underwent structured treatment interruptions (STIs). Analyses of length variation and of clonal sequences demonstrated highly unpredictable evolution, which may limit the strengthening of HIV-specific immune responses by STIs because of the variability in exposure to viral antigens.

Autores: Martinez-Picado J, Frost SD, Izquierdo N, Morales-Lopetegi K, Marfil S, Puig T, Cabrera C, Clotet B, Ruiz L.

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Irsi Caixa

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