No detection of the NS5B S282T mutation in treatment-naïve genotype 1 HCV/HIV-1 coinfected patients using deep sequencing

No detection of the NS5B S282T mutation in treatment-naïve genotype 1 HCV/HIV-1 coinfected patients using deep sequencing

Fecha de publicación online: 21/10/2013 Fecha de publicación en papel: 1 Diciembre 2013 Revista: Journal of Clinical Virology

Abstract:

BACKGROUND: The S282T mutation is the main variant described associated with resistance to nucleos(t)ide analogues hepatitis C virus (HCV) NS5B polymerase inhibitors.

OBJECTIVE: We aimed here to investigate whether this substitution pre-existed in treatment naive HCV/HIV-1 coinfected patients.

STUDY DESIGN: NS5B polymerase deep sequencing was performed at a median coverage per base of 4471 in 16 patient samples.

RESULTS: No S282T variant was detected in the 16 analyzed samples.

CONCLUSION: This finding is in agreement with the high genetic barrier of nucleoside analogues NS5B polymerase inhibitors and the clinical efficacy of these compounds.

Autores: Franco, S., Casadellà, M., Noguera-Julian, M., Clotet, B., Tural, C., Paredes, R., Martinez, M.A.

Suscríbete a la newsletter

Back to Top
Irsi Caixa

Impulsado por:

Fundación 'La Caixa' Generalitat de Catalunya - Departament de Salut

 

HR Excellence in Research

Miembro de:

Cerca

Con la colaboración de: