Our group focuses on translational studies of HIV-1 infection and both basic and applied research into potential new HIV/AIDS therapeutic strategies. We work closely with the HIV unit of the Germans Trias i Pujol University Hospital, which attends some 2,000 people with HIV/AIDS. Our research programme focuses on four priority areas:
1) HIV eradication. We evaluate replication persistence in the presence of an effective antiretroviral treatment, study the location and impact of viral reservoirs and conduct clinical studies focused on developing therapeutic interventions aimed at reducing viral reservoirs and eradicating the disease. Our group is leader of the first consortium (IciStem) for allogeneic stem cell transplantation in patients with HIV, a technique which potentially represents a major advance in the field.
2) HIV pathogenesis mediated by dendritic cells. Research is based around our discovery of the axis of recognition between viral gangliosides and the Siglec-1 receptor, its role in trans-infection and the design of therapeutic strategies that can take advantage of this mechanism.
3) Extreme HIV infection phenotypes. We evaluate the immune and virological characteristics of rapid progressors, spontaneous controllers, viraemic non-progressors and exposed uninfected individuals in order to add to the body of knowledge on infection pathogenesis, with a view to applying this knowledge in new customized therapeutic, diagnostic and follow-up strategies for patients.
4) New therapeutic strategies. We focus especially on antiretroviral treatment and immunotherapies, mechanisms of emerging resistance to treatments and impact on viral fitness.
Javier Martinez-Picado is a Catalan Institute for Research and Advanced Studies (ICREA) research professor at IrsiCaixa — which has as its mission to advance clinical research and translate results into patient care — and an associate professor at the University of Vic...
Curriculum
Pre-doctoral researcher
Cristina Gálvez Celada
cgalvez@irsicaixa.es
Laboratory technician
Itziar Erkizia
ierkizia@irsicaixa.es
Principal Investigator
Javier Martínez-Picado
jmpicado@irsicaixa.es
Clinical cohort coordinator
Judith Dalmau
jdalmau@irsicaixa.es
Senior laboratory technician
Maria C. Puertas Castro
mcpuertas@irsicaixa.es
Post-doctoral researcher
Maria Salgado
msalgado@irsicaixa.es
Statistician
Víctor Urrea Gales
vurrea@irsicaixa.es
Pre-doctoral researcher
Sílvia Bernal
sbernal@irsicaixa.es
Post-doctoral researcher
Patricia Resa-Infante
prinfante@irsicaixa.es
Pre-doctoral researcher
Xabier Muñiz
xmuniz@irsicaixa.es
Post-doctoral researcher
Jakub Chojnacki
jchojnacki@irsicaixa.es
Laboratory technician
María del Carmen García Guerrero
mcgarcia@irsicaixa.es
Pre-doctoral researcher
Ángel Bayón Gil
abayon@irsicaixa.es
