No detection of the NS5B S282T mutation in treatment-naïve genotype 1 HCV/HIV-1 coinfected patients using deep sequencing

No detection of the NS5B S282T mutation in treatment-naïve genotype 1 HCV/HIV-1 coinfected patients using deep sequencing

Online publication: 21/10/2013 Printed publication: 1 December 2013 Journal: Journal of Clinical Virology

Abstract:

BACKGROUND: The S282T mutation is the main variant described associated with resistance to nucleos(t)ide analogues hepatitis C virus (HCV) NS5B polymerase inhibitors.

OBJECTIVE: We aimed here to investigate whether this substitution pre-existed in treatment naive HCV/HIV-1 coinfected patients.

STUDY DESIGN: NS5B polymerase deep sequencing was performed at a median coverage per base of 4471 in 16 patient samples.

RESULTS: No S282T variant was detected in the 16 analyzed samples.

CONCLUSION: This finding is in agreement with the high genetic barrier of nucleoside analogues NS5B polymerase inhibitors and the clinical efficacy of these compounds.

Authors: Franco, S., Casadellà, M., Noguera-Julian, M., Clotet, B., Tural, C., Paredes, R., Martinez, M.A.

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