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  • Early antigen presentation of protective HIV-1 KF11Gag and KK10Gag epitopes from incoming viral particles facilitates rapid recognition of infected cells by specific CD8+ T cells

    Henrik N. Kløverpris1, Rebecca P. Payne1, Jonah B. Sacha2, Jane T. Rasaiyaah3, Fabian Chen4, Masafumi Takiguchi5, Otto O. Yang6, Greg J. Towers3, Philip Goulder1 and Julia G. Prado7

     

    1Department of Paediatrics, University of Oxford, Peter Medawar Building, OX1 3SY, United Kingdom 2Vaccine & Gene Therapy Institute, Oregon National Primate Research Center, Oregon Health & Science University, USA 3Medical Research Council Centre for Medical Molecular Virology, Division of Infection and Immunity, University College London, London, United Kingdom 4Department of Sexual Health, Royal Berkshire Hospital, Reading RG1 5AN, United Kingdom 5Centre for AIDS Research, Kumamoto University, 2-2-1 Honjo, Kumamoto 860-0811, Japan 6Departments of Medicine and Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA 7AIDS Research Institute IrsiCaixa, Hospital Germans Trias i Pujol, 08916 Badalona, Spain

    Early antigen presentation of protective HIV-1 KF11Gag and KK10Gag epitopes from incoming viral particles facilitates rapid recognition of infected cells by specific CD8+ T cells. Kløverpris HN, Payne RP, Sacha JB, Rasaiyaah JT, Chen F, Takiguchi M, Yang OO, Towers GJ, Goulder P, Prado JG. J Virol. 2012 Dec 19. [Epub ahead of print] PMID: 23255798 [PubMed - as supplied by publisher]

  • Siglec-1 Is a Novel Dendritic Cell Receptor That Mediates HIV-1 Trans-Infection Through Recognition of Viral Membrane Gangliosides

    Nuria Izquierdo-Useros1, Maier Lorizate2, Maria C. Puertas1, Maria T. Rodriguez-Plata1, Nadine Zangger3, Elina Erikson2, Maria Pino1, Itziar Erkizia1, Bärbel Glass2, Bonaventura Clotet1, Oliver T. Keppler2, Amalio Telenti3, Hans-Georg Kräusslich2, Javier Martinez-Picado1,4
    1AIDS Research Institute IrsiCaixa, Institut d’Investigació en Ciències de la Salut Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Spain, 2Department of Infectious Diseases, Virology, Universitätsklinikum Heidelberg, Heidelberg, Germany, 3Institute of Microbiology, University Hospital Center and University of Lausanne, Lausanne, Switzerland, 4Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain

    Izquierdo-Useros N, Lorizate M, Puertas MC, Rodriguez-Plata MT, Zangger N, et al. (2012) Siglec-1 Is a Novel Dendritic Cell Receptor That Mediates HIV-1 Trans-Infection Through Recognition of Viral Membrane Gangliosides. PLoS Biol 10(12): e1001448. doi:10.1371/journal.pbio.1001448

  • HIV-1 capture and antigen presentation by dendritic cells: enhanced viral capture does not correlate with better T-cell activation

    Maria T. Rodriguez-Plata1, Alejandra Urrutia2, Sylvain Cardinaud2, Maria J. Buzón1, Nuria Izquierdo-Useros1, Julia G. Prado1, Maria C. Puertas1, Itziar Erkizia1, Pierre-Grégoire Coulon2, Samandhy Cedeño1, Bonaventura Clotet1, Arnaud Moris2, Javier Martinez-Picado1,3
    1AIDS Research Institute IrsiCaixa, Hospital Germans Trias i Pujol, Universitat Autònoma de Barcelona; 2INSERM, Unité Mixte de Recherche Scientifique 945 (UMRS-945), Infection et Immunité, Université Pierre et Marie Curie; 3Institució Catalana de Recerca i Estudis Avançats, (ICREA)

    J Immunol. 2012 Jun 15;188(12):6036-45. Epub 2012 May 11

  • Noncyclam tetraamines inhibit CXC chemokine receptor type 4 and target glioma-initiating cells

    Laia Ros-Blanco1, Judit Anido2, Ramon Bosser3, José Esté4, Bonaventura Clotet4, Ana Kosoy3, Luis Ruíz-Ávila3, Jordi Teixidó1, Joan Seoane2, and José I. Borrell1

    1Grup d’Enginyeria Molecular, Institut Químic de Sarrià, Universitat Ramon Llull, Via Augusta 390, E-08017 Barcelona, Spain 2Translational Research Program, Vall d'Hebron Institute of Oncology (VHIO), Vall d’Hebron University Hospital, E-08035 Barcelona, Spain and Universitat Autònoma de Barcelona, E-08193 Cerdanyola del Vallès, Spain 3Janus Development SL, Parc Científic Barcelona, Baldiri Reixac 10-12, E-08028 Barcelona, Spain 4IrsiCaixa, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, E-08916 Badalona, Spain

    J Med Chem. 2012 Sep 13;55(17):7560-70. doi: 10.1021/jm300862u. Epub 2012 Aug 29

  • Trans-infection but not infection from within endosomal compartments after cell-to-cell HIV-1 transfer to CD4+ T cells

    Permanyer M, Ballana E, Badia R, Pauls E, Clotet B, Esté JA.

    IrsiCaixa, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, 08916 Badalona, Spain

    J Biol Chem. 2012 Sep 14;287(38):32017-26. doi: 10.1074/jbc.M112.343293. Epub 2012 Jul 30.